Understanding cell-matrix interaction and mechanosensing to counteract diseases

18th October 2021.  Giancarlo Forte, St. Anne’s University, Brno, Czech Republic and University of Turku, Finland

Understanding cell-matrix interaction and mechanosensing to counteract diseases.

Giancarlo Forte of the International Clinical Research Center, St. Anne’s University, Brno, Czech Republic and University of Turku, Finland will give a talk at 5.00 pm on the 18th of October on Understanding cell-matrix interaction and mechanosensing to counteract diseases. The talk will be available online at the following link:

https://us02web.zoom.us/meeting/register/tZAqduGhqz0pGdNm1rjHhecNtpkxJnqu_RrM

The seminar poster that can be downloaded here. All College students are invited to attend, especially undergraduates and postgraduates reading Biology, Biotechnology, Pharmaceutical Sciences and Medicine and PhD students engaged in research projects in the biomedical area.

Abstract
Downstream of ECM remodelling, the aberrant activation of the mechanosensing apparatus contributes to the establishment and progression of age-related pathologies, like cancer and cardiovascular diseases. My group is interested in understanding how ECM remodelling determines opposite consequences in rather different biological systems, like tumors and the heart. In particular, we focus on dissecting the molecular mechanisms controlling the divergent response to mechanical stress of cardiomyocytes - which are induced to hypertrophy - and cancer cells - which tend to proliferate and disseminate. Mechanosensitive proteins have been recently identified that respond to ECM pathological remodelling and trigger the growth and dissemination of different tumor types. Our group demonstrated how ECM pathological remodelling determines changes in the assembly of focal adhesions through the mechanical control of Yes Associated Protein (YAP) in breast cancer. We also described how YAP aberrant activation contributes to cardiac ECM pathological remodelling in heart failure. In this context, we recently identified RNA binding protein hnRNPC conferring mRNA metabolism sensitivity to cardiac ECM mechanical turmoil and impinging on the alternative splicing of components of mechanosensitive pathways.  In the presentation, I will describe our strategy to disentangle the contribution of pathological mechanosensing to hyperplastic and hypertrophic phenotypes and will briefly discuss how we plan to exploit 3D complex disease models based on induced pluripotent stem cells (iPSCs), and tumor spheroids derived from patients or cell lines to answer our scientific questions.

Biography
The speaker is Deputy Director for Science of the International Clinical Research Center, an Institute of excellence funded by European Union within St. Anne’s University Hospital in Brno, Czech Republic (FNUSA-ICRC).  He also serves as Group Leader of the Center for Translational Medicine (CTM) at FNUSA-ICRC and holds an Adjunct Professor position in Cell Biology and Biomaterials at the University of Turku (Finland). Dr. Forte obtained his Master Degree in Cellular and Molecular Biology in 2000 at the University of Rome Tor Vergata (Italy), where he also completed his PhD in 2005 in Experimental Pathophysiology.

Image
Computer image of a fibrin network. Courtesy of Farzan Beroz, Princeton University.

 

 

Thursday, 14 October 2021 09:14

The p53 tumour suppressor

On the 15th of October Roger Leng of the University of Alberta, Canada will give a talk at 5.00 pm on The p53 Pathway in Cancer and Potential Therapeutic Applications. The talk will be available online at the following link:
https://us02web.zoom.us/meeting/register/tZAvd-6rqDsiHdLi_lePKKy1lhKBQW7VY8DB

The product of the p53 gene is a transcription factor with crucial tumour suppressor functions. Mutations in the p53 gene occur very frequently in human cancers and contribute to tumour onset and/or progression.  The seminar will discuss research the role of p53 in cancer and new approaches to restore p53 activity in cells that have lost it.

The seminar poster that can be downloaded here. Further details, including a seminar abstract and a biographical sketch of the speaker are available at this page.  All College students are invited to attend, especially undergraduates and posgraduates reading Biology, Biotechnology, Pharmaceutical Sciences and Medicine and PhD students incolved in life science projects.

Image: immunofluorescent staining of human cells for p53 (green) and actin (red).






The p53 Pathway in Cancer and Potential Therapeutic Applications

Roger Leng, 15th October 2021 
The p53 Pathway in Cancer and Potential Therapeutic Applications

Roger Leng of the University of Alberta, Canada will give a talk at 5.00 pm on the 15th of October on The p53 Pathway in Cancer and Potential Therapeutic Applications. The talk will be available online at the following link:

https://us02web.zoom.us/meeting/register/tZAvd-6rqDsiHdLi_lePKKy1lhKBQW7VY8DB

The seminar poster that can be downloaded here. All College students are invited to attend, especially undergraduates and postgraduates reading Biology, Biotechnology, Pharmaceutical Sciences and Medicine and PhD students engaged in research projects in the biomedical area.

Abstract
The seminar will offer background information about the p53 and ubiquitin-proteasome pathways and will next cover the speaker's own research on p53-tumors and the regulation of the activity of members of p53 protein members inside the cells regulation. Finally the seminar will offer an outline of the author's future programmes of research in the p53 field.

Image
Brown/black staining of prostate cancer cells with an anti-p53 antibody (PreproTech) demonstrates the predominat nuclear localisation of the protein (darker staining).

 

 

Wednesday, 13 October 2021 06:38

The CCR5 Receptor

On the 13th of October Luca Vangelista of the University of Nazarbayev, Kazakhstan will give a talk at 5.00 pm on CCR5: a Crossroad for Infection and Inflammation. The talk will be available online at the following link:
https://us02web.zoom.us/j/88600327505?pwd=TDZLYlBoYTgzcmNIMXI3UlZ5dy94Zz09


The CCR5 receptor plays a key role in the entrance of HIV in target cells. HIV is the virus causing the Acquired Immuno Deficienty Syndrome (AIDS), a disease that has killed over 36 million people from 1981 to 2020.  The seminar will discuss research on CCR5 in the context of the HIV infection as well as other roles of this receptor in inflammation. 

The seminar poster that can be downloaded here. Further details, including a seminar abstract and a biographical sketch of the speaker are available at this page.   All College students are invited to attend, especially undergraduates and posgraduates reading Biology, Biotechnology, Pharmaceutical Sciences and Medicine and PhD students incolved in life science projects.

Image: an electron micrograph of the HIV virus (courtesy of H Gelderblom, Robert Koch Institute, Berlin).






CCR5: a Crossroad for Infection and Inflammation

Luca Vangelista, 13th October 2021  
CCR5: a Crossroad for Infection and Inflammation

Luca Vangelists of the University of Nazarbayev, Kazakhstan will give a talk at 5.00 pm on the 13th of October on CCR5: a Crossroad for Infection and Inflammation. The talk will be available online at the following link:

https://us02web.zoom.us/j/88600327505?pwd=TDZLYlBoYTgzcmNIMXI3UlZ5dy94Zz09

The seminar poster that can be downloaded here. All College students are invited to attend, especially those reading Biology, Biotechnology, Pharmaceutical Sciences and Medicine.

Abstract
CCR5 and its interaction with chemokine ligands have been crucial for understanding and tackling HIV-1 entry into target cells. Over time, CCR5 was found to be central in a growing number of pathophysiological conditions. Expressed on various cell types, CCR5 plays a pivotal role in the inflammatory response by directing cells to sites of inflammation, ultimately resulting in major diseases such as cancer and atherosclerosis. Many infectious agents use CCR5 either by a direct interaction with the receptor during their pathogenesis (e.g., HIV-1 and S. aureus) or by indirect strategies exploiting receptor activation. The massive efforts devoted to combat HIV-1 entry by interfering with CCR5, and the subsequent production of chemokine ligand variants, small chemical compounds, and other molecular entities and strategies, may set the therapeutic standards for a wealth of different pathologies.

Biography
- Degree in Chemistry and Pharmaceutical Technology at the University of Padova, Italy.
- PhD in Molecular Biology at the University of Heidelberg, Germany, for the PhD work at the Structural Biology Program of the European Molecular Biology Laboratory (EMBL) headquarters in Heidelberg.
- Postdoctoral Fellow in the Molecular Immunology Group at the International Centre for Genetic Engineering and Biotechnology in Trieste, Italy.
- Research Scientist at the San Raffaele Scientific Institute and the University of Milan, Italy.
- Group Leader (Protein Engineering and Therapeutics) at the San Raffaele Scientific Institute, Milan, Italy.
- Associate Professor & Director Master in Molecular Medicine at the Nazarbayev University School of Medicine, Nur-Sultan (Astana), Kazakhstan.
- Visiting Scientist at GSK (UK), University of Vienna (Austria), Sanquin Research Amsterdam (Netherland), Biozentrum Basel (Switzerland) and Osel Inc. (USA).

Image
The structure of a CCR5 peptide involved in the interaction with the HIV gp120 protein (pdb code: 2l87)

 

 

Volta Debating Society (VDES)

Debate is the the cornerstone of democratic culture and a quintessential feature of University life. There is tradition of formal University-based debates in a number of Institutions in the English-speaking world and, following in this tradition, Volta has promoted its own Volta Debating Society (VDES) with the aim to offer students basic debating skills, foster internal debate on major topics and encourage an inter-collegiate debating context. The style of these debates will follow that of British Parliamentary debates and the ultimate aim of these activities is to assemble a University-wide team that will represent the University of Pavia at the annual World Universities Debating Championship  due to take place in Belgrade in 2022 and in Madrid in 2023. 

The College thanks Arianna Armanetti (currently an MSc student in Physics, earlier a College undergraduate) for promoting the debating culture inside Volta and for providing a basic course of debating sklls in the academic year 2020/21and for acting as the first secretary to the Volta Debating Society for the academic years 2020/21 and 2021/22.  The following College students were the the first members of tthe VDES: Federico Bertelli, Giulia Bonasegale, Raffaele Castellucci, Andrea Cerbone, Mircea Codrea, Davide Gianatti, Giacomo Maggiorano, Chiara Mogliazza, Alessandra Ria and Marco Silvestri. 
Internal and inter-collegiate debating events will be reported in the News & Events section of the College web site and details of the 2021/22 'The Art and Technique of Debating' Course will be published alongside the details of other College Courses (personale development, language, computing, etc) in the earlier part of the 2021/22 academic year.

The following students enrolled in the VDES for the academic year 2021/22.  Arianna Armanetti  has agreed to act as Secretary to the Society for ths academic year.

Leonardo    Beretta
Raffaele    Castellucci
Federica    Paparella
Elia A    Perli
Ines    Shopi
Mehdi   Alipour Masoumabad
Arianna    Armanetti
Annalisa    Barone
Andrea    Caiulo
Paolo    Catarsi
Mircea A    Codrea
Davide    Gianatti
Abimbola C    Ogunyele
Alice    Salacrist
Marco    Silvestri


Image: a debate of the Cambridge Union, the oldest known University Debating Society (founded 1815).

Saturday, 24 April 2021 18:55

Entrepreunership Club - Pavia

Elisa Seghetti, a member of Collegio Nuovo and co-founder of Entrepreneurship Club Pavia (E-Club Pavia for short) is bringing E-Club Pavia to the attention of Volta students and is inviting members of Volta them to the next Club event.

E-Club Pavia is a University group aiming to create a network of University students with a serious interest in entrepreneurship and is organising a meeting online on Thursday, the 29th of April at 7.30 pm in collaboration with the startup Thesis4U and the student group ImGestionale during which 4 startup companies will outline their ideas and business plans and will illustrate in the process how to 'pitch' such presentations.

Business inclined members of Collegio A Volta are welcome to join the E-Club Pavia event on Thursday 29th at the following url  https://thesisforyou.com/iscriviti-allevento-su-come-fare-il-pitch/.

The College expresses its gratitude to Elisa Seghetti for extending this invitation to the members of Volta.



RNA Vaccines

22 April 2021. 
George P Smith, University of Missouri, Columbia

At 6.00 pm on 22 April 2021 George P Smith will give a lecture entitled: RNA Vaccines for Pandemic Threats (subtitle:Promise of the technology and economic justice in its development. The lecture will be online and is accessible through this link.

George Smith is Curators' Distinguished Professor Emeritus of Biological Sciences at the University of Missouri in Columbia, Missouri.  He was born in Norwalk, Connecticut in the United States. He obtained a degree in Biology at Haverford College in Pennsylvania (1963) and a PhD in Bacteriology and Immunology at Harvard University (1970). After completing post-doctoral research at the University of Wisconsin in Madison, he moved to the University of Missouri in Columbia where he remained there for the rest of his career excpet for two years at Duke University (1983–1984).

George P Smith adapted fundamental principles of evolution (diversity and selection) to laboratory science and specifically to protein engineering.  He developed a strategy - phage display - that enables rapid selection of protein varian for specific functions or new functions and for this work he was awarded a share of the Nobel Prize for Chemistry in 2018.

The poster of the lecture is available here.

Image
Image: People queuing for food aid during the Covid pandemic in Pretoria, South Africa (20 May 2020, Reuters)

Sunday, 11 April 2021 08:17

RNA Vaccines

College will host a lecture entitled RNA Vaccines for Pandemic Threats. Promise of the technology and economic justice in its development to be given online at 6.00 pm on 22 April 2021 by 

George P Smith , Professor of Italian - Emeritus - and Fellow of St John’s College at Cambridge University. The lecture can be joined through this link.

George Smith is Curators' Distinguished Professor Emeritus of Biological Sciences at the University of Missouri in Columbia, Missouriwas born in Norwalk, Connecticut in the United States and made fundamental contributions fto the field of protein engineering by developing the phage display technology for which he was awarded a share of the 2018 Nobel Prize for Chemistry. 

The poster of the lecture is available here and further information can be found on this page. All College students are warmly invited to join this major science lecture.

Image: A three dimensional model of a coronavirus (Center for Disease Control and Prevention, CDC).



Ut Pictura Poesis et Poesis Pictura

15 April 2021. 
Patrick Boyde, St John's College, Cambridge

At 6.00 pm on 15 April 2021Patrick Boyde will give a lecture entitled: Ut Pictura Poesis & ut Poesis Pictura (subtitle: Simbiosi e interazioni tra Dante e i grandi artisti toscani all’epoca dei Comuni). The lecture will be online and is accessible through this link.

Patrick Boyde is Professor Emeritus of Italian at Cambridge University and Fellow Borderer of St John’s College at Cambridge University. He is a also a Fellow of the British Academy (1987), a Member of Accademia Nazionale dei Lincei and a Honorary Member of the American Dante Society.  He received Gold Medals from the City of Florence (1995) and the Italian Republic (1998) and the title of ‘Commendatore Ordine al Merito della Repubblica Italiana’ from Carlo Azeglio Ciampi, then President of the Republic for for outstanding contributions to Italian Culture.

Patrick Boyde has researched the work od Dante Alighieri from new theoretical perspectives at the crossroad of literature, philosophy and figurative arts. He published 5 books on Dante : Dante's Lyric Poetry (with Kenelm Foster, in two volumes), Oxford 1967; Dante's Style in his Lyric Poetry, Cambridge 1971 (translated in Italian as Retorica e stile nelle liriche di Dante, Napoli, Liguori editore, 1979); Dante Philomythes and Philosopher: Man in the Cosmos, Cambridge 1981 (translated in Italian as L'uomo nel cosmo: Filosofia della natura e poesia in Dante, Bologna, Il Mulino, 1984); Night Thoughts on Italian Poetry and Art, Cambridge 1985; Perception and Passion in Dante's ‘Comedy’, Cambridge 1993 (translated in Italian as ‘Lo color del core’. Visione, passione e ragione in Dante, Napoli, Liguori editore, 2002); Human Vices and Human Worth in Dante’s ‘Comedy’, Cambridge 2000, work that received the Sapegno Prize in 2002. The titles in bold are known among the scholars as Parick Boydes’s ‘trilogy’. Patrick Boyde is widely regarded as one of the major scholars of Dante’s work of all times.

The poster of the lecture is available here. The video of lecture is available here.

Image
Dante's Inferno (canto XVIII) from La Divina Commedia Illustrata da Sandro Botticelli. Engraving on parchment, painted in ink and partly colored. At the Kupferstichkabinett (Museum of Prints and Drawings) in Berlin.


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