On Tuesday the 5th of June 2018 Marek Cieplak of the Institute of Physics of the Polish Institute of Sciences will give a seminar on Proteins at fluid-fluid interfaces at 11.00 am in the College Lecture theatre.
The behaviour of proteins is greatly affected by their environment, namely their presence in solution or at water-air, water-oil or water-water interfacese. The physiological activity of certain proteins, for example lung surfactant proteins, depends indeed on their ability to partition specific domains in the water environment and other ones in the air envirnoment thus regulating the surface tension of the alveoli or their role as a barrier to pathogens. The study of proteins at fluid-fluid interfaces, however, impacts on pathology as well as it may impact on their propensity to oligomerise and form protein aggregates as found in certain neurodegenerative diseasese (Parkinson, Alzheimer, etc). M Cieplak will discuss the conformational changes that proteins may encounter at fluid-fluid interfaces and how this may promote the formation of high order protein aggregates.
All College students are warmly invited to attend this seminar lecture, espcially students reading Medicine, Biology, Biotechnology and Pharmaceutical Sciences. The poster of the lecture can be downloaded here.
